Could Kang The Conqueror Defeat The MCU's Thanos?

As Kang, then going by the moniker He Who Remains, explains to Loki in the Season 1 finale of "Loki," there are infinite versions of himself scattered across the Multiverse, many of whom are hell-bent on conquering every universe in existence. However, they will temporarily team up to take out a shared threat before fighting among themselves once more. Thanos, on the other hand, doesn't concern himself with other universes or variants of himself, with his goal being to kill half of all life in his universe of origin.

If multiple Kangs ally against Thanos, they'd easily outnumber the purple-chinned tyrant. Not only would they be able to coordinate their attacks across time, space, and universes, but they'd also be sharing technology from all those places. Even if Thanos defeats a hundred versions of Kang, a hundred more would take their place, and he would lose the odds eventually. It would be game over for the Mad Titan.

On the other hand, if Kang gets unlucky and has to fight both Thanos and other versions of himself, he'd almost certainly lose — although to be fair, he'd mostly be losing to himself, not to Thanos. Ultimately, while a hypothetical conflict would be tough for both parties, Kang's advantages against Thanos would be more than enough to tip the scales in his favor.